Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

doi:10.1038/s41467-018-04818-0

	Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
	Kim, Kun-Yong ; Tanaka, Yoshiaki ; Su, Juan ; Cakir, Bilal ; Xiang, Yangfei; Patterson, Benjamin ; Ding, Junjun ; Jung, Yong-Wook ; Kim, Ji-Hyun ; Hysolli, Eriona ; Lee, Haelim ; Dajani, Rana ; Kim, Jonghwan ; Zhong, Mei ; Lee, Jeong-Heon ; Skalnik, David ; Lim, Jeong Mook ; Sullivan, Gareth J.; Wang, Jianlong ; Park, In-Hyun
	2018
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	9
发表状态	已发表
DOI	10.1038/s41467-018-04818-0
摘要	Embryonic stem cells (ESCs) maintain pluripotency through unique epigenetic states. When ESCs commit to a specific lineage, epigenetic changes in histones and DNA accompany the transition to specialized cell types. Investigating how epigenetic regulation controls lineage specification is critical in order to generate the required cell types for clinical applications. Uhrf1 is a widely known hemi-methylated DNA-binding protein, playing a role in DNA methylation through the recruitment of Dnmt1 and in heterochromatin formation alongside G9a, Trim28, and HDACs. Although Uhrf1 is not essential in ESC self-renewal, it remains elusive how Uhrf1 regulates cell specification. Here we report that Uhrf1 forms a complex with the active trithorax group, the Setd1a/COMPASS complex, to maintain bivalent histone marks, particularly those associated with neuroectoderm and mesoderm specification. Overall, our data demonstrate that Uhrf1 safeguards proper differentiation via bivalent histone modifications.
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收录类别	SCI
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000437101700013
WOS关键词	MAINTENANCE DNA METHYLATION ; HISTONE H3 ; MAMMALIAN-CELLS ; RNA-SEQ ; PROTEIN ; DIFFERENTIATION ; CHROMATIN ; POLYCOMB ; COMPLEX ; RECOGNITION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120148
专题	个人在本单位外知识产出
通讯作者	Park, In-Hyun
作者单位	1.Yale Sch Med, Dept Genet, Yale Stem Cell Ctr, Yale Child Study Ctr, New Haven, CT 06520 USA 2.Second Mil Med Univ, Dept Cell Biol, Shanghai 200433, Peoples R China 3.Icahn Sch Med Mt Sinai, Black Family Stem Cell Inst, Dept Cell Dev & Regenerat Biol, New York, NY 10029 USA 4.CHA Univ, CHA Gangnam Med Ctr, Dept Obstet & Gynecol, Seoul 06135, South Korea 5.Hashemite Univ, Dept Biol & Biotechnol, Zarqa 13115, Jordan 6.Harvard Univ, Radcliffe Inst Adv Studies, Cambridge, MA 02138 USA 7.Univ Texas Austin, Inst Cellular & Mol Biol, Ctr Syst & Synthet Biol, Dept Mol Biosci, Austin, TX 78712 USA 8.Yale Sch Med, Yale Stem Cell Ctr, Dept Cell Biol, New Haven, CT 06520 USA 9.Indiana Univ Purdue Univ, Sch Sci, Dept Biol, Indianapolis, IN 46202 USA 10.Seoul Natl Univ, Dept Agr Biotechnol, Seoul 08826, South Korea 11.Univ Oslo, Hybrid Technol Hub Ctr Excellence, Inst Basic Med Sci, Dept Mol Med, N-0372 Oslo, Norway 12.Oslo Univ Hosp, Inst Immunol, Norwegian Ctr Stem Cell Res, N-0372 Oslo, Norway 13.Univ Oslo, N-0372 Oslo, Norway
推荐引用方式 GB/T 7714	Kim, Kun-Yong,Tanaka, Yoshiaki,Su, Juan,et al. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a[J]. NATURE COMMUNICATIONS,2018,9.
APA	Kim, Kun-Yong.,Tanaka, Yoshiaki.,Su, Juan.,Cakir, Bilal.,Xiang, Yangfei.,...&Park, In-Hyun.(2018).Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.NATURE COMMUNICATIONS,9.
MLA	Kim, Kun-Yong,et al."Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a".NATURE COMMUNICATIONS 9(2018).