ShanghaiTech University Knowledge Management System
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappa B signaling | |
Vallabhapurapu, Sivakumar; Matsuzawa, Atsushi; Zhang, WeiZhou; Tseng, Ping-Hui; Keats, Jonathan J.; Wang, Haopeng; Vignali, Dario A. A.; Bergsagel, P. Leif; Karin, Michael | |
2008 | |
发表期刊 | NATURE IMMUNOLOGY |
ISSN | 1529-2908 |
卷号 | 9期号:12页码:1364-1370 |
发表状态 | 已发表 |
DOI | 10.1038/ni.1678 |
摘要 | The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative nuclear factor-kappa B (NF-kappa B) signaling in resting cells by targeting NF-kappa B-inducing kinase (NIK) for ubiquitin-dependent degradation, thus preventing processing of the NF-kappa B2 precursor protein p100 to release p52. However, the respective functions of TRAF2 and TRAF3 in NIK degradation and activation of alternative NF-kappa B signaling have remained elusive. We now show that CD40 or BAFF receptor activation result in TRAF3 degradation in a cIAP1-cIAP2- and TRAF2-dependent way owing to enhanced cIAP1, cIAP2 TRAF3-directed ubiquitin ligase activity. Receptor-induced activation of cIAP1 and cIAP2 correlated with their K63-linked ubiquitination by TRAF2. Degradation of TRAF3 prevented association of NIK with the cIAP1-cIAP2-TRAF2 ubiquitin ligase complex, which resulted in NIK stabilization and NF-kappa B2-p100 processing. Constitutive activation of this pathway causes perinatal lethality and lymphoid defects. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
WOS记录号 | WOS:000260888700011 |
WOS关键词 | CELL-DEATH ; MULTIPLE-MYELOMA ; NF-KAPPA-B2 P100 ; CRITICAL ROLES ; IMMUNE-SYSTEM ; RECEPTOR ; TNF ; KINASE ; ALPHA ; CD40 |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120078 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Karin, Michael |
作者单位 | 1.Univ Calif San Diego, Ctr Canc, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 93093 USA 2.Univ Calif San Diego, Ctr Canc, Dept Pathol, Lab Gene Regulat & Signal Transduct, San Diego, CA 93093 USA 3.Mayo Clin Arizona, Ctr Comprehens Canc, Scottsdale, AZ 85259 USA 4.St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA |
推荐引用方式 GB/T 7714 | Vallabhapurapu, Sivakumar,Matsuzawa, Atsushi,Zhang, WeiZhou,et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappa B signaling[J]. NATURE IMMUNOLOGY,2008,9(12):1364-1370. |
APA | Vallabhapurapu, Sivakumar.,Matsuzawa, Atsushi.,Zhang, WeiZhou.,Tseng, Ping-Hui.,Keats, Jonathan J..,...&Karin, Michael.(2008).Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappa B signaling.NATURE IMMUNOLOGY,9(12),1364-1370. |
MLA | Vallabhapurapu, Sivakumar,et al."Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappa B signaling".NATURE IMMUNOLOGY 9.12(2008):1364-1370. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。