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De novo formation of a distinct coronary vascular population in neonatal heart | |
2014 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
卷号 | 345期号:6192页码:90-94 |
发表状态 | 已发表 |
DOI | 10.1126/science.1251487 |
摘要 | The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we found that a substantial portion of postnatal coronary vessels arise de novo in the neonatal mouse heart, rather than expanding from preexisting embryonic vasculature. Our data show that lineage conversion of neonatal endocardial cells during trabecular compaction generates a distinct compartment of the coronary circulation located within the inner half of the ventricular wall. This lineage conversion occurs within a brief period after birth and provides an efficient means of rapidly augmenting the coronary vasculature. This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease. |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000338284400057 |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
WOS关键词 | ENDOTHELIAL-CELLS ; ENDOCARDIAL CELLS ; ARTERIES ; FORM ; BIOLOGY |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119873 |
专题 | 个人在本单位外知识产出 |
共同第一作者 | Hu, Tianyuan; Zhang, Hui; He, Lingjuan |
通讯作者 | Zhou, Bin |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, Inst Nutr Sci,Grad Sch, Shanghai 200031, Peoples R China 2.Fudan Univ, Zhongshan Hosp, Shanghai 200032, Peoples R China 3.Inst Biotechnol, State Key Lab Prote, Beijing 100071, Peoples R China 4.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China 5.Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA 6.Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Tian, Xueying,Hu, Tianyuan,Zhang, Hui,et al. De novo formation of a distinct coronary vascular population in neonatal heart[J]. SCIENCE,2014,345(6192):90-94. |
APA | Tian, Xueying.,Hu, Tianyuan.,Zhang, Hui.,He, Lingjuan.,Huang, Xiuzhen.,...&Zhou, Bin.(2014).De novo formation of a distinct coronary vascular population in neonatal heart.SCIENCE,345(6192),90-94. |
MLA | Tian, Xueying,et al."De novo formation of a distinct coronary vascular population in neonatal heart".SCIENCE 345.6192(2014):90-94. |
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