ShanghaiTech University Knowledge Management System
Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover | |
2013 | |
发表期刊 | PLOS BIOLOGY |
ISSN | 1544-9173 |
EISSN | 1545-7885 |
卷号 | 11期号:11 |
发表状态 | 已发表 |
DOI | 10.1371/journal.pbio.1001721 |
摘要 | Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers. Hedgehog signaling has an unusual reception system consisting of two transmembrane proteins, Patched receptor and Smoothened signal transducer. Although activation of Smoothened and its downstream signal transduction have been intensively studied, less is known about how Patched receptor is regulated, and particularly how this regulation contributes to appropriate Hedgehog signal transduction. Here we identified a novel role of Smurf E3 ligase in regulating Hedgehog signaling by controlling Patched ubiquitination and turnover. Moreover, we showed that Smurf-mediated Patched ubiquitination depends on Smo activity in wing discs. Mechanistically, we found that Smo interacts with Smurf and promotes it to mediate Patched ubiquitination by targeting the K1261 site in Ptc. The further mathematic modeling analysis reveals that a bidirectional control of activation of Smo involving Smurf and Patched is important for signal-receiving cells to precisely interpret external signals, thereby maintaining Hedgehog signaling reliability. Finally, our data revealed an evolutionarily conserved role of Smurf proteins in controlling Hh signaling by targeting Ptc during development. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
WOS类目 | Biochemistry & Molecular Biology ; Biology |
WOS记录号 | WOS:000330352200023 |
出版者 | PUBLIC LIBRARY SCIENCE |
WOS关键词 | GERMLINE STEM-CELLS ; PROTEIN-KINASE-A ; MEMBRANE-PROTEIN ; MORPHOGEN GRADIENT ; FEEDBACK LOOP ; GENE ENCODES ; HECT FAMILY ; DROSOPHILA ; RECEPTOR ; UBIQUITINATION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119864 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Huang, Shoujun; Zhao, Yun; Chen, Dahua |
作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai, Peoples R China 3.Chinese Acad Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China 4.Chinese Acad Sci, Ctr Computat & Evolutionary Biol, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol Conservat Biol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Huang, Shoujun,Zhang, Zhao,Zhang, Chunxia,et al. Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover[J]. PLOS BIOLOGY,2013,11(11). |
APA | Huang, Shoujun.,Zhang, Zhao.,Zhang, Chunxia.,Lv, Xiangdong.,Zheng, Xiudeng.,...&Chen, Dahua.(2013).Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover.PLOS BIOLOGY,11(11). |
MLA | Huang, Shoujun,et al."Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover".PLOS BIOLOGY 11.11(2013). |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。