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| The developmental transcriptome of Drosophila melanogaster | |
Graveley, Brenton R.; Brooks, Angela N.; Carlson, JosephW.; Duff, Michael O.; Landolin, Jane M.; Yang, Li  ; Artieri, Carlo G.; van Baren, Marijke J.; Boley, Nathan; Booth, Benjamin W.; Brown, James B.; Cherbas, Lucy; Davis, Carrie A.; Dobin, Alex; Li, Renhua; Lin, Wei; Malone, John H.; Mattiuzzo, Nicolas R.; Miller, David; Sturgill, David; Tuch, Brian B.; Zaleski, Chris; Zhang, Dayu; Blanchette, Marco; Dudoit, Sandrine; Eads, Brian; Green, Richard E.; Hammonds, Ann; Jiang, Lichun; Kapranov, Phil; Langton, Laura; Perrimon, Norbert; Sandler, Jeremy E.; Wan, Kenneth H.; Willingham, Aarron; Zhang, Yu; Zou, Yi; Andrews, Justen; Bickel, Peter J.; Brenner, Steven E.; Brent, Michael R.; Cherbas, Peter; Gingeras, Thomas R.; Hoskins, Roger A.; Kaufman, Thomas C.; Oliver, Brian; Celniker, Susan E.
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| 2011 | |
| Source Publication | NATURE
 |
| ISSN | 0028-0836 |
| EISSN | 1476-4687 |
| Volume | 471Issue:7339Pages:473-479 |
| Status | 已发表 |
| DOI | 10.1038/nature09715 |
| Abstract | Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless, its genome still contains unannotated coding and non-coding genes, transcripts, exons and RNA editing sites. Full discovery and annotation are pre-requisites for understanding how the regulation of transcription, splicing and RNA editing directs the development of this complex organism. Here we used RNA-Seq, tiling microarrays and cDNA sequencing to explore the transcriptome in 30 distinct developmental stages. We identified 111,195 new elements, including thousands of genes, coding and non-coding transcripts, exons, splicing and editing events, and inferred protein isoforms that previously eluded discovery using established experimental, prediction and conservation-based approaches. These data substantially expand the number of known transcribed elements in the Drosophila genome and provide a high-resolution view of transcriptome dynamics throughout development. |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000288702200054 |
| Publisher | NATURE PUBLISHING GROUP |
| WOS Keyword | GENE-EXPRESSION ; FUNCTIONAL ELEMENTS ; BITHORAX COMPLEX ; ABDOMINAL-B ; IDENTIFICATION ; GENOMES ; TARGETS |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119824 |
| Collection | 个人在本单位外知识产出 |
| Corresponding Author | Graveley, Brenton R.; Celniker, Susan E. |
| Affiliation | 1.Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, 263 Farmington Ave, Farmington, CT 06030 USA 2.Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA 3.Univ Calif Berkeley, Lawrence Berkeley Lab, Dept Genome Dynam, Berkeley, CA 94720 USA 4.NIDDK, Sect Dev Genom, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA 5.Washington Univ, Ctr Genome Sci, St Louis, MO 63108 USA 6.Washington Univ, Dept Comp Sci, St Louis, MO 63108 USA 7.Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA 8.Indiana Univ, Ctr Genom & Bioinformat, Bloomington, IN 47405 USA 9.Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA 10.Indiana Univ, Dept Biol, Bloomington, IN 47405 USA 11.Life Technol, Res & Dev, Genet Syst Div, Foster City, CA 94404 USA 12.Amgen Inc, Genome Anal Unit, San Francisco, CA 94080 USA 13.Stowers Inst Med Res, Kansas City, MO 64110 USA 14.Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66160 USA 15.Univ Calif Berkeley, Sch Publ Hlth, Div Biostat, Berkeley, CA 94720 USA 16.Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA 17.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 18.Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA 19.Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA 20.Affymetrix, Santa Clara, CA 95051 USA |
| Recommended Citation GB/T 7714 | Graveley, Brenton R.,Brooks, Angela N.,Carlson, JosephW.,et al. The developmental transcriptome of Drosophila melanogaster[J]. NATURE,2011,471(7339):473-479. |
| APA | Graveley, Brenton R..,Brooks, Angela N..,Carlson, JosephW..,Duff, Michael O..,Landolin, Jane M..,...&Celniker, Susan E..(2011).The developmental transcriptome of Drosophila melanogaster.NATURE,471(7339),473-479. |
| MLA | Graveley, Brenton R.,et al."The developmental transcriptome of Drosophila melanogaster".NATURE 471.7339(2011):473-479. |
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