Mapping Human Genetic Diversity in Asia

doi:10.1126/science.1177074

	Mapping Human Genetic Diversity in Asia
	Abdulla, Mahmood Ameen ; Ahmed, Ikhlak ; Assawamakin, Anunchai ; Bhak, Jong ; Brahmachari, Samir K.; Calacal, Gayvelline C.; Chaurasia, Amit ; Chen, Chien-Hsiun ; Chen, Jieming ; Chen, Yuan-Tsong ; Chu, Jiayou ; Cutiongco-de la Paz, Eva Maria C.; De Ungria, Maria Corazon A.; Delfin, Frederick C.; Edo, Juli ; Fuchareon, Suthat ; Ghang, Ho ; Gojobori, Takashi ; Han, Junsong ; Ho, Sheng-Feng ; Hoh, Boon Peng ; Huang, Wei ; Inoko, Hidetoshi ; Jha, Pankaj ; Jinam, Timothy A.; Jin, Li ; Jung, Jongsun ; Kangwanpong, Daoroong ; Kampuansai, Jatupol ; Kennedy, Giulia C.; Khurana, Preeti ; Kim, Hyung-Lae ; Kim, Kwangjoong ; Kim, Sangsoo ; Kim, Woo-Yeon ; Kimm, Kuchan ; Kimura, Ryosuke ; Koike, Tomohiro ; Kulawonganunchai, Supasak ; Kumar, Vikrant ; Lai, Poh San ; Lee, Jong-Young ; Lee, Sunghoon ; Liu, Edison T.; Majumder, Partha P.; Mandapati, Kiran Kumar ; Marzuki, Sangkot ; Mitchell, Wayne ; Mukerji, Mitali ; Naritomi, Kenji ; Ngamphiw, Chumpol ; Niikawa, Norio ; Nishida, Nao ; Oh, Bermseok ; Oh, Sangho ; Ohashi, Jun ; Oka, Akira ; Ong, Rick ; Padilla, Carmencita D.; Palittapongarnpim, Prasit ; Perdigon, Henry B.; Phipps, Maude Elvira ; Png, Eileen ; Sakaki, Yoshiyuki ; Salvador, Jazelyn M.; Sandraling, Yuliana ; Scaria, Vinod ; Seielstad, Mark ; Sidek, Mohd Ros ; Sinha, Amit ; Srikummool, Metawee ; Sudoyo, Herawati ; Sugano, Sumio ; Suryadi, Helena ; Suzuki, Yoshiyuki ; Tabbada, Kristina A.; Tan, Adrian ; Tokunaga, Katsushi ; Tongsima, Sissades ; Villamor, Lilian P.; Wang, Eric ; Wang, Ying ; Wang, Haifeng ; Wu, Jer-Yuarn ; Xiao, Huasheng ; Xu, Shuhua; Yang, Jin Ok ; Shugart, Yin Yao ; Yoo, Hyang-Sook ; Yuan, Wentao ; Zhao, Guoping ; Zilfalil, Bin Alwi
	2009
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
卷号	326 期号:5959 页码:1541-1545
发表状态	已发表
DOI	10.1126/science.1177074
摘要	Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
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收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000272623600059
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS关键词	POPULATION-STRUCTURE ; WIDE ANALYSIS ; ADMIXTURE ; GEOGRAPHY ; UYGHURS ; HISTORY ; EUROPE
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119821
专题	个人在本单位外知识产出
通讯作者	Jin, Li; Liu, Edison T.; Seielstad, Mark; Xu, Shuhua
作者单位	1.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China 2.Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia 3.Univ Malaya, Fac Arts & Social Sci, Dept Anthropol, Kuala Lumpur 50603, Malaysia 4.CSIR, Inst Genom & Integrat Biol, Delhi 110007, India 5.Mahidol Univ, Puttamonthon 73170, Nakornpathom, Thailand 6.Natl Ctr Genet Engn & Biotechnol, Genome Inst, Biostat & Informat Lab, Pathum Thani 12120, Thailand 7.KRIBB, KOBIC, Taejon 305806, South Korea 8.Univ Philippines, Nat Sci Res Inst, DNA Anal Lab, Quezon City 1101, Philippines 9.Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan 10.Genome Inst Singapore, Singapore 138672, Singapore 11.Chinese Acad Med Sci, Inst Med Biol, Kunming, Peoples R China 12.Univ Philippines Manila, Natl Inst Hlth, Inst Human Genet, Ermita Manila 1000, Philippines 13.Res Org Informat & Syst, Ctr Informat Biol, Mishima, Shizuoka 4118540, Japan 14.Res Org Informat & Syst, DNA Data Bank Japan, Natl Inst Genet, Mishima, Shizuoka 4118540, Japan 15.Natl Inst Adv Ind Sci & Technol, Biomed Informat Res Ctr, Koto Ku, Tokyo 1350064, Japan 16.Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China 17.Univ Sains Malaysia, Sch Med Sci, Ctr Human Genome, Kubang Kerian 16150, Kelantan, Malaysia 18.Chinese Natl Human Genome Ctr Shanghai, MOST Shanghai Lab Dis & Hlth Genom, Shanghai 201203, Peoples R China 19.Tokai Univ, Sch Med, Dept Mol Life Sci, Div Mol Med Sci & Mol Med, Isehara, Kanagawa A2591193, Japan 20.Fudan Univ, Sch Life Sci, MOE Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China 21.Korea Natl Inst Hlth, Seoul 122701, South Korea 22.Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50202, Thailand 23.Affymetrix, Genom Collaborat, Santa Clara, CA 95051 USA 24.Veracyte, San Francisco, CA 94080 USA 25.Ctr Genom Applicat, New Delhi 110020, India 26.Soongsil Univ, Seoul 156743, South Korea 27.Eulji Univ, Coll Med, Taejon 301832, South Korea 28.Univ Tokyo, Grad Sch Med, Dept Human Genet, Bunkyo Ku, Tokyo 1130033, Japan 29.Natl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119074, Singapore 30.DSO Natl Labs, Def Med & Environm Res Inst, Populat Genet Lab, Singapore 117510, Singapore 31.Indian Stat Inst, Kolkata 700108, India 32.Eijkman Inst Mol Biol, Jakarta 10430, Indonesia 33.Informat Expt Therapeut Ctr, Singapore 138669, Singapore 34.Nanyang Technol Univ, Sch Comp Engn, Div Informat Sci, Singapore 639798, Singapore 35.Univ Ryukyus, Fac Med, Dept Med Genet, Okinawa 9030215, Japan 36.Natl Sci & Technol Dev Agcy, Pathum Thani 12120, Thailand 37.Monash Univ, Bandar Sunway 46150, Selangor, Malaysia 38.RIKEN, Genom Sci Ctr, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan 39.Univ Hong Kong, Dept Biochem, Pokfulam, Hong Kong, Peoples R China 40.Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Lab Funct Genom,Shirokanedai Lab,Minato Ku, Tokyo 1088639, Japan 41.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Soc, Partner Inst Computat Biol, Shanghai 200031, Peoples R China 42.NIMH, Genom Res Branch, NIH, Bethesda, MD 20892 USA 43.Hlth Sci Univ Hokkaido, Res Inst Personalized Hlth Sci, Tobetsu 0610293, Japan
推荐引用方式 GB/T 7714	Abdulla, Mahmood Ameen,Ahmed, Ikhlak,Assawamakin, Anunchai,et al. Mapping Human Genetic Diversity in Asia[J]. SCIENCE,2009,326(5959):1541-1545.
APA	Abdulla, Mahmood Ameen.,Ahmed, Ikhlak.,Assawamakin, Anunchai.,Bhak, Jong.,Brahmachari, Samir K..,...&Zilfalil, Bin Alwi.(2009).Mapping Human Genetic Diversity in Asia.SCIENCE,326(5959),1541-1545.
MLA	Abdulla, Mahmood Ameen,et al."Mapping Human Genetic Diversity in Asia".SCIENCE 326.5959(2009):1541-1545.