Mapping Human Genetic Diversity in Asia
Abdulla, Mahmood Ameen; Ahmed, Ikhlak; Assawamakin, Anunchai; Bhak, Jong; Brahmachari, Samir K.; Calacal, Gayvelline C.; Chaurasia, Amit; Chen, Chien-Hsiun; Chen, Jieming; Chen, Yuan-Tsong; Chu, Jiayou; Cutiongco-de la Paz, Eva Maria C.; De Ungria, Maria Corazon A.; Delfin, Frederick C.; Edo, Juli; Fuchareon, Suthat; Ghang, Ho; Gojobori, Takashi; Han, Junsong; Ho, Sheng-Feng; Hoh, Boon Peng; Huang, Wei; Inoko, Hidetoshi; Jha, Pankaj; Jinam, Timothy A.; Jin, Li; Jung, Jongsun; Kangwanpong, Daoroong; Kampuansai, Jatupol; Kennedy, Giulia C.; Khurana, Preeti; Kim, Hyung-Lae; Kim, Kwangjoong; Kim, Sangsoo; Kim, Woo-Yeon; Kimm, Kuchan; Kimura, Ryosuke; Koike, Tomohiro; Kulawonganunchai, Supasak; Kumar, Vikrant; Lai, Poh San; Lee, Jong-Young; Lee, Sunghoon; Liu, Edison T.; Majumder, Partha P.; Mandapati, Kiran Kumar; Marzuki, Sangkot; Mitchell, Wayne; Mukerji, Mitali; Naritomi, Kenji; Ngamphiw, Chumpol; Niikawa, Norio; Nishida, Nao; Oh, Bermseok; Oh, Sangho; Ohashi, Jun; Oka, Akira; Ong, Rick; Padilla, Carmencita D.; Palittapongarnpim, Prasit; Perdigon, Henry B.; Phipps, Maude Elvira; Png, Eileen; Sakaki, Yoshiyuki; Salvador, Jazelyn M.; Sandraling, Yuliana; Scaria, Vinod; Seielstad, Mark; Sidek, Mohd Ros; Sinha, Amit; Srikummool, Metawee; Sudoyo, Herawati; Sugano, Sumio; Suryadi, Helena; Suzuki, Yoshiyuki; Tabbada, Kristina A.; Tan, Adrian; Tokunaga, Katsushi; Tongsima, Sissades; Villamor, Lilian P.; Wang, Eric; Wang, Ying; Wang, Haifeng; Wu, Jer-Yuarn; Xiao, Huasheng; Xu, Shuhua; Yang, Jin Ok; Shugart, Yin Yao; Yoo, Hyang-Sook; Yuan, Wentao; Zhao, Guoping; Zilfalil, Bin Alwi
2009
Source PublicationSCIENCE
ISSN0036-8075
EISSN1095-9203
Volume326Issue:5959Pages:1541-1545
Status已发表
DOI10.1126/science.1177074
Abstract

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

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Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000272623600059
PublisherAMER ASSOC ADVANCEMENT SCIENCE
WOS KeywordPOPULATION-STRUCTURE ; WIDE ANALYSIS ; ADMIXTURE ; GEOGRAPHY ; UYGHURS ; HISTORY ; EUROPE
Original Document TypeArticle
Citation statistics
Cited Times:451[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119821
Collection个人在本单位外知识产出
Corresponding AuthorJin, Li; Liu, Edison T.; Seielstad, Mark; Xu, Shuhua
Affiliation
1.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
2.Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia
3.Univ Malaya, Fac Arts & Social Sci, Dept Anthropol, Kuala Lumpur 50603, Malaysia
4.CSIR, Inst Genom & Integrat Biol, Delhi 110007, India
5.Mahidol Univ, Puttamonthon 73170, Nakornpathom, Thailand
6.Natl Ctr Genet Engn & Biotechnol, Genome Inst, Biostat & Informat Lab, Pathum Thani 12120, Thailand
7.KRIBB, KOBIC, Taejon 305806, South Korea
8.Univ Philippines, Nat Sci Res Inst, DNA Anal Lab, Quezon City 1101, Philippines
9.Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan
10.Genome Inst Singapore, Singapore 138672, Singapore
11.Chinese Acad Med Sci, Inst Med Biol, Kunming, Peoples R China
12.Univ Philippines Manila, Natl Inst Hlth, Inst Human Genet, Ermita Manila 1000, Philippines
13.Res Org Informat & Syst, Ctr Informat Biol, Mishima, Shizuoka 4118540, Japan
14.Res Org Informat & Syst, DNA Data Bank Japan, Natl Inst Genet, Mishima, Shizuoka 4118540, Japan
15.Natl Inst Adv Ind Sci & Technol, Biomed Informat Res Ctr, Koto Ku, Tokyo 1350064, Japan
16.Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China
17.Univ Sains Malaysia, Sch Med Sci, Ctr Human Genome, Kubang Kerian 16150, Kelantan, Malaysia
18.Chinese Natl Human Genome Ctr Shanghai, MOST Shanghai Lab Dis & Hlth Genom, Shanghai 201203, Peoples R China
19.Tokai Univ, Sch Med, Dept Mol Life Sci, Div Mol Med Sci & Mol Med, Isehara, Kanagawa A2591193, Japan
20.Fudan Univ, Sch Life Sci, MOE Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China
21.Korea Natl Inst Hlth, Seoul 122701, South Korea
22.Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50202, Thailand
23.Affymetrix, Genom Collaborat, Santa Clara, CA 95051 USA
24.Veracyte, San Francisco, CA 94080 USA
25.Ctr Genom Applicat, New Delhi 110020, India
26.Soongsil Univ, Seoul 156743, South Korea
27.Eulji Univ, Coll Med, Taejon 301832, South Korea
28.Univ Tokyo, Grad Sch Med, Dept Human Genet, Bunkyo Ku, Tokyo 1130033, Japan
29.Natl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119074, Singapore
30.DSO Natl Labs, Def Med & Environm Res Inst, Populat Genet Lab, Singapore 117510, Singapore
31.Indian Stat Inst, Kolkata 700108, India
32.Eijkman Inst Mol Biol, Jakarta 10430, Indonesia
33.Informat Expt Therapeut Ctr, Singapore 138669, Singapore
34.Nanyang Technol Univ, Sch Comp Engn, Div Informat Sci, Singapore 639798, Singapore
35.Univ Ryukyus, Fac Med, Dept Med Genet, Okinawa 9030215, Japan
36.Natl Sci & Technol Dev Agcy, Pathum Thani 12120, Thailand
37.Monash Univ, Bandar Sunway 46150, Selangor, Malaysia
38.RIKEN, Genom Sci Ctr, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
39.Univ Hong Kong, Dept Biochem, Pokfulam, Hong Kong, Peoples R China
40.Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Lab Funct Genom,Shirokanedai Lab,Minato Ku, Tokyo 1088639, Japan
41.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Soc, Partner Inst Computat Biol, Shanghai 200031, Peoples R China
42.NIMH, Genom Res Branch, NIH, Bethesda, MD 20892 USA
43.Hlth Sci Univ Hokkaido, Res Inst Personalized Hlth Sci, Tobetsu 0610293, Japan
Recommended Citation
GB/T 7714
Abdulla, Mahmood Ameen,Ahmed, Ikhlak,Assawamakin, Anunchai,et al. Mapping Human Genetic Diversity in Asia[J]. SCIENCE,2009,326(5959):1541-1545.
APA Abdulla, Mahmood Ameen.,Ahmed, Ikhlak.,Assawamakin, Anunchai.,Bhak, Jong.,Brahmachari, Samir K..,...&Zilfalil, Bin Alwi.(2009).Mapping Human Genetic Diversity in Asia.SCIENCE,326(5959),1541-1545.
MLA Abdulla, Mahmood Ameen,et al."Mapping Human Genetic Diversity in Asia".SCIENCE 326.5959(2009):1541-1545.
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