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Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling | |
Zhu, Shu; Pan, Wen; Shi, Peiqing; Gao, Hanchao; Zhao, Fang; Song, Xinyang; Liu, Yan; Zhao, Lihua; Li, Xiaoxia; Shi, Yufang | |
2010 | |
发表期刊 | JOURNAL OF EXPERIMENTAL MEDICINE |
ISSN | 0022-1007 |
EISSN | 1540-9538 |
卷号 | 207期号:12页码:2647-2662 |
发表状态 | 已发表 |
DOI | 10.1084/jem.20100703 |
摘要 | Interleukin 17 (IL-17) plays critical roles in the pathogenesis of various autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). How the signals triggered by this powerful inflammatory cytokine are controlled to avoid abnormal inflammatory responses is not well understood. In this study, we report that TRAF3 is a receptor proximal negative regulator of IL-17 receptor (IL-17R) signaling. TRAF3 greatly suppressed IL-17-induced NF-kappa B and mitogen-activated protein kinase activation and subsequent production of inflammatory cytokines and chemokines. Mechanistically, the binding of TRAF3 to IL-17R interfered with the formation of the receptor signaling activation complex IL-17R-Act1-TRAF6, resulting in suppression of downstream signaling. TRAF3 markedly inhibited IL-17-induced expression of inflammatory cytokine and chemokine genes in vivo and consequently delayed the onset and greatly reduced the incidence and severity of EAE. Thus, TRAF3 is a negative regulator of IL-17R proximal signaling. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Immunology ; Research & Experimental Medicine |
WOS类目 | Immunology ; Medicine, Research & Experimental |
WOS记录号 | WOS:000285505000011 |
出版者 | ROCKEFELLER UNIV PRESS |
WOS关键词 | TH17 CELL-DIFFERENTIATION ; CENTRAL-NERVOUS-SYSTEM ; KAPPA-B ACTIVATION ; EPITHELIAL-CELLS ; MICROARRAY ANALYSIS ; FAMILY-MEMBERS ; IL-17 ; TRAF3 ; INFLAMMATION ; TRANSDUCTION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119734 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Qian, Youcun |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China 3.Cleveland Clin, Lerner Res Inst, Dept Immunol, Cleveland, OH 44195 USA |
推荐引用方式 GB/T 7714 | Zhu, Shu,Pan, Wen,Shi, Peiqing,et al. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2010,207(12):2647-2662. |
APA | Zhu, Shu.,Pan, Wen.,Shi, Peiqing.,Gao, Hanchao.,Zhao, Fang.,...&Qian, Youcun.(2010).Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling.JOURNAL OF EXPERIMENTAL MEDICINE,207(12),2647-2662. |
MLA | Zhu, Shu,et al."Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling".JOURNAL OF EXPERIMENTAL MEDICINE 207.12(2010):2647-2662. |
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