Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling
Zhu, Shu; Pan, Wen; Shi, Peiqing; Gao, Hanchao; Zhao, Fang; Song, Xinyang; Liu, Yan; Zhao, Lihua; Li, Xiaoxia; Shi, Yufang
2010
发表期刊JOURNAL OF EXPERIMENTAL MEDICINE
ISSN0022-1007
EISSN1540-9538
卷号207期号:12页码:2647-2662
发表状态已发表
DOI10.1084/jem.20100703
摘要

Interleukin 17 (IL-17) plays critical roles in the pathogenesis of various autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). How the signals triggered by this powerful inflammatory cytokine are controlled to avoid abnormal inflammatory responses is not well understood. In this study, we report that TRAF3 is a receptor proximal negative regulator of IL-17 receptor (IL-17R) signaling. TRAF3 greatly suppressed IL-17-induced NF-kappa B and mitogen-activated protein kinase activation and subsequent production of inflammatory cytokines and chemokines. Mechanistically, the binding of TRAF3 to IL-17R interfered with the formation of the receptor signaling activation complex IL-17R-Act1-TRAF6, resulting in suppression of downstream signaling. TRAF3 markedly inhibited IL-17-induced expression of inflammatory cytokine and chemokine genes in vivo and consequently delayed the onset and greatly reduced the incidence and severity of EAE. Thus, TRAF3 is a negative regulator of IL-17R proximal signaling.

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收录类别SCI
WOS研究方向Immunology ; Research & Experimental Medicine
WOS类目Immunology ; Medicine, Research & Experimental
WOS记录号WOS:000285505000011
出版者ROCKEFELLER UNIV PRESS
WOS关键词TH17 CELL-DIFFERENTIATION ; CENTRAL-NERVOUS-SYSTEM ; KAPPA-B ACTIVATION ; EPITHELIAL-CELLS ; MICROARRAY ANALYSIS ; FAMILY-MEMBERS ; IL-17 ; TRAF3 ; INFLAMMATION ; TRANSDUCTION
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119734
专题个人在本单位外知识产出
通讯作者Qian, Youcun
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China
3.Cleveland Clin, Lerner Res Inst, Dept Immunol, Cleveland, OH 44195 USA
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GB/T 7714
Zhu, Shu,Pan, Wen,Shi, Peiqing,et al. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2010,207(12):2647-2662.
APA Zhu, Shu.,Pan, Wen.,Shi, Peiqing.,Gao, Hanchao.,Zhao, Fang.,...&Qian, Youcun.(2010).Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling.JOURNAL OF EXPERIMENTAL MEDICINE,207(12),2647-2662.
MLA Zhu, Shu,et al."Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling".JOURNAL OF EXPERIMENTAL MEDICINE 207.12(2010):2647-2662.
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