Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors

doi:10.1038/s41586-020-2223-y

	Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors
	Jin, Zhenming 1,2,3,4; Du, Xiaoyu 3,4; Xu, Yechun 5; Deng, Yongqiang 6; Liu, Meiqin 7; Zhao, Yao1,2 ; Zhang, Bing1,2 ; Li, Xiaofeng 6; Zhang, Leike 7; Peng, Chao 8; Duan, Yinkai1,2 ; Yu, Jing1,2 ; Wang, Lin1,2 ; Yang, Kailin 9; Liu, Fengjiang1,2 ; Jiang, Rendi 7; Yang, Xinglou 7; You, Tian1,2 ; Liu, Xiaoce1,2 ; Yang, Xiuna1,2 ; Bai, Fang1,2 ; Liu, Hong 5; Liu, Xiang 10; Guddat, Luke W.11; Xu, Wenqing1,2,8 ; Xiao, Gengfu 7; Qin, Chengfeng 6; Shi, Zhengli 7; Jiang, Hualiang1,2,5 ; Rao, Zihe1,2,3,4,10 ; Yang, Haitao1,2
	2020-04-09
发表期刊	NATURE (IF:50.5[JCR-2023],54.4[5-Year])
ISSN	0028-0836
EISSN	1476-4687
卷号	582 期号:7811 页码:289–293
发表状态	已发表
DOI	10.1038/s41586-020-2223-y
摘要	A programme of structure-assisted drug design and high-throughput screening identifies six compounds that inhibit the main protease of SARS-CoV-2, demonstrating the ability of this strategy to isolate drug leads with clinical potential.
收录类别	SCI ; SCIE
资助项目	National Key R&D Program of China[2017YFC0840300][2020YFA0707500] ; Project of International Cooperation and Exchanges NSFC[81520108019] ; Science and Technology Commission of Shanghai Municipality[20431900200] ; Department of Science and Technology of Guangxi Zhuang Autonomous Region[2020AB40007]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000537932300001
出版者	NATURE PUBLISHING GROUP
WOS关键词	RESPIRATORY SYNDROME-CORONAVIRUS ; VIRUS MAIN PROTEASE ; SARS ; PROTEINASE ; EBSELEN ; SPECIFICITIES ; PREVENTION ; DOCKING ; COMPLEX ; BINDING
原始文献类型	Article
引用统计	被引频次：2382[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119226
专题	生命科学与技术学院_博士生免疫化学研究所免疫化学研究所_特聘教授组_饶子和组免疫化学研究所_特聘教授组_蒋华良组生命科学与技术学院_硕士生生命科学与技术学院_PI研究组_许文青组免疫化学研究所_PI研究组_杨海涛组免疫化学研究所_PI研究组_白芳组
共同第一作者	Du, Xiaoyu; Xu, Yechun; Deng, Yongqiang; Liu, Meiqin
通讯作者	Jiang, Hualiang; Rao, Zihe; Yang, Haitao
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Tsinghua Univ, Sch Life Sci, Struct Biol Lab, Beijing, Peoples R China 4.Tsinghua Univ, Sch Med, Beijing, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai, Peoples R China 6.Acad Mil Med Sci, Beijing Inst Microbiol & Epidemiol, Dept Virol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China 7.Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, CAS Key Lab Special Pathogens, Wuhan, Peoples R China 8.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Natl Facil Prot Sci Shanghai, Shanghai, Peoples R China 9.Cleveland Clin, Taussig Canc Ctr, Cleveland, OH 44106 USA 10.Nankai Univ, State Key Lab Med Chem Biol, Frontiers Sci Ctr Cell Response, Coll Life Sci,Coll Pharm, Tianjin, Peoples R China 11.Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia
第一作者单位	免疫化学研究所; 生命科学与技术学院
通讯作者单位	免疫化学研究所; 生命科学与技术学院
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Jin, Zhenming,Du, Xiaoyu,Xu, Yechun,et al. Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors[J]. NATURE,2020,582(7811):289–293.
APA	Jin, Zhenming.,Du, Xiaoyu.,Xu, Yechun.,Deng, Yongqiang.,Liu, Meiqin.,...&Yang, Haitao.(2020).Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors.NATURE,582(7811),289–293.
MLA	Jin, Zhenming,et al."Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors".NATURE 582.7811(2020):289–293.