Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer

doi:10.1126/sciadv.aaw9960

	Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer
	Qin, Yuanyuan 1,2,3; Chen, Weilong 1,2,3; Jiang, Guojuan 1,2; Zhou, Lei 1,2,3; Yang, Xiaoli 1,2; Li, Hongqi 4,5; He, Xueyan 1,2; Wang, Han-lin6,7 ; Zhou, Yu-bo 7; Huang, Shenglin 1,2; Liu, Suling 1,2
	2020-02
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	6 期号:8
发表状态	已发表
DOI	10.1126/sciadv.aaw9960
摘要	Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, little is known about the regulatory mechanisms of MSN in TNBC. We found that MSN significantly stimulated breast cancer cell proliferation and invasion in vitro and tumor growth in vivo, requiring the phosphorylation of MSN and a nucleoprotein NONO-assisted nuclear localization of phosphorylated MSN with protein kinase C (PKC) and then the phosphoryl-ation activation of CREB signaling by PKC. Our study also demonstrated that targeting MSN, NONO, or CREB significantly inhibited breast tumor growth in vivo. These results introduce a new understanding of MSN function in breast cancer and provide favorable evidence that MSN or its downstream molecules might serve as new targets for TNBC treatment.
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Basic Research Program of China (973 Program)[2016YFA0101202] ; [YJRC1603] ; National Natural Science Foundation of China[81530075] ; Ministry of Science and Technology of the People's Republic of China[2015CB553800] ; Program of Shanghai Academic Research Leader[2019LJ04] ; [IDH 1340042]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000514842000004
出版者	AMER ASSOC ADVANCEMENT SCIENCE
EI入藏号	20200808206676
EI主题词	Cell proliferation ; Diseases ; Phosphorylation ; Tumors
EI分类号	Bioengineering and Biology:461 ; Chemical Reactions:802.2
WOS关键词	ERM PROTEINS ; MOESIN ; METASTASIS ; DISEASE ; PHOSPHORYLATION ; PROLIFERATION ; PROGRESSION ; STATISTICS ; EXPRESSION ; INVASION
原始文献类型	Journal article (JA)
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/114845
专题	生命科学与技术学院_硕士生
通讯作者	Liu, Suling
作者单位	1.Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll,Canc Inst, Key Lab Breast Canc Shanghai,Innovat Ctr Cell Sig, Shanghai 200032, Peoples R China 2.Fudan Univ, Inst Biomed Sci, Shanghai Med Coll,Canc Inst, Key Lab Breast Canc Shanghai,Innovat Ctr Cell Sig, Shanghai 200032, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Innate Immun & Chron Dis, Hefei 230027, Anhui, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Endoscopy Ctr, Shanghai, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Endoscopy Res Inst, Shanghai, Peoples R China 6.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Qin, Yuanyuan,Chen, Weilong,Jiang, Guojuan,et al. Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer[J]. SCIENCE ADVANCES,2020,6(8).
APA	Qin, Yuanyuan.,Chen, Weilong.,Jiang, Guojuan.,Zhou, Lei.,Yang, Xiaoli.,...&Liu, Suling.(2020).Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer.SCIENCE ADVANCES,6(8).
MLA	Qin, Yuanyuan,et al."Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer".SCIENCE ADVANCES 6.8(2020).