Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II
Liu, Keli1,2; Lin, Liangyu1; Li, Qing1; Xue, Yueqing1; Zheng, Fanjun1; Wang, Guan1; Zheng, Chunxing1; Du, Liming1; Hu, Mingyuan1; Huang, Yin1; Shao, Changshun3; Kong, Xiangyin1; Melino, Gerry4; Shi, Yufang1,2,3; Wang, Ying1
2020-02-04
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume117Issue:5Pages:2462-2472
Status已发表
DOI10.1073/pnas.1914553117
AbstractPreadipocytes can give rise to either white adipocytes or beige adipocytes. Owing to their distinct abilities in nutrient storage and energy expenditure, strategies that specifically promote "beiging" of adipocytes hold great promise for counterbalancing obesity and metabolic diseases. Yet, factors dictating the differentiation fate of adipocyte progenitors remain to be elucidated. We found that stearoyl-coenzyme A desaturase 1 (Scd1)-deficient mice, which resist metabolic stress, possess augmentation in beige adipocytes under basal conditions. Deletion of Scd1 in mature adipocytes expressing Fabp4 or Ucp1 did not affect thermogenesis in mice. Rather, Scd1 deficiency shifted the differentiation fate of preadipocytes from white adipogenesis to beige adipogenesis. Such effects are dependent on succinate accumulation in adipocyte progenitors, which fuels mitochondrial complex II activity. Suppression of mitochondrial complex II by Atpenin A5 or oxaloacetic acid reverted the differentiation potential of Scd1-deficient preadipocytes to white adipocytes. Furthermore, supplementation of succinate was found to increase beige adipocyte differentiation both in vitro and in vivo. Our data reveal an unappreciated role of Scd1 in determining the cell fate of adipocyte progenitors through succinate-dependent regulation of mitochondrial complex II.
Keywordstearoyl-coenzyme A desaturase 1 (Scd1) beige fat biogenesis preadipocytes succinate mitochondrial complex II
Indexed BySCI
Language英语
Funding ProjectMinistry of Foreign Affairs and International Cooperation Italy-China Science and Technology Cooperation[PGR00961]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000512340900038
PublisherNATL ACAD SCIENCES
WOS KeywordSTEAROYL-COA DESATURASE-1 ; DEFICIENCY PROTECTS MICE ; ADIPOSE-TISSUE ; BROWN ADIPOCYTES ; ENERGY ; GENE ; CELL ; ADIPOGENESIS ; METABOLISM ; WEIGHT
Original Document TypeArticle
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/105325
Collection生命科学与技术学院_博士生
生命科学与技术学院
Corresponding AuthorShi, Yufang; Wang, Ying
Affiliation1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci,CAS Key Lab Tissue Microen, Shanghai 200031, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
3.Soochow Univ, Inst Translat Med, State Key Lab Radiat Med & Protect, Affiliated Hosp 1, Suzhou 215123, Peoples R China
4.Ist Dermopat Immacolata IDI IRCCS, Biochem Lab, I-00100 Rome, Italy
5.Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy
First Author AffilicationSchool of Life Science and Technology
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Liu, Keli,Lin, Liangyu,Li, Qing,et al. Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2020,117(5):2462-2472.
APA Liu, Keli.,Lin, Liangyu.,Li, Qing.,Xue, Yueqing.,Zheng, Fanjun.,...&Wang, Ying.(2020).Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,117(5),2462-2472.
MLA Liu, Keli,et al."Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117.5(2020):2462-2472.
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