Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration
Tang, Juan1; Wang, Haixiao1; Huang, Xiuzhen1; Li, Fei1; Zhu, Huan1; Li, Yan1; He, Lingjuan1; Zhang, Hui2; Pu, Wenjuan1; Liu, Kuo1,2; Zhao, Huan1; Bentzon, Jacob Fog3,4; Yu, Ying5,6; Ji, Yong7,8; Nie, Yu9,10; Tian, Xueying11; Zhang, Li12; Gao, Dong1,13; Zhou, Bin1,2,11,13
2020-01
Source PublicationCELL STEM CELL
ISSN1934-5909
Volume26Issue:1Pages:81-+
Status已发表
DOI10.1016/j.stem.2019.11.010
AbstractRapid regeneration of smooth muscle after vascular injury is essential for maintaining arterial function. The existence and putative roles of resident vascular stem cells (VSCs) in artery repair are controversial, and vessel regeneration is thought to be mediated by proliferative expansion of pre-existing smooth muscle cells (SMCs). Here, we performed cell fate mapping and single-cell RNA sequencing to identify Sca1(+) VSCs in the adventitial layer of artery walls. After severe injury, Sca1(+) VSCs migrate into the medial layer and generate de novo SMCs, which subsequently expand more efficiently compared with preexisting smooth muscle. Genetic lineage tracing using dual recombinases distinguished a Sca1(+)PDGFRa(+) VSC subpopulation that generates SMCs, and genetic ablation of Sca1(+) VSCs or specific knockout of Yap1 in Sca1(+) VSCs significantly impaired artery repair. These findings provide genetic evidence of a bona fide Sca1(+) VSC population that produces SMCs and delineates their critical role in vessel repair.
Indexed BySCI
Language英语
Funding ProjectMajor Program of the Development Fund for the Shanghai Zhangjiang National Innovation Demonstration Zone (Stem Cell Clinical Technology Transformation Platform)[ZJ2018-ZD-004]
WOS Research AreaCell Biology
WOS SubjectCell & Tissue Engineering ; Cell Biology
WOS IDWOS:000505213700010
PublisherCELL PRESS
EISSN1875-9777
WOS KeywordDIPHTHERIA-TOXIN RECEPTOR ; CARDIAC NEURAL CREST ; PROGENITOR CELLS ; MESENCHYMAL TRANSITION ; NEOINTIMAL FORMATION ; ENDOTHELIAL-CELLS ; ORIGIN ; ATHEROSCLEROSIS ; CONTRIBUTE ; AORTA
Original Document TypeArticle
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/105113
Collection生命科学与技术学院_PI研究组_张辉组
生命科学与技术学院_特聘教授组_周斌组
生命科学与技术学院_硕士生
Corresponding AuthorZhang, Li; Gao, Dong; Zhou, Bin
Affiliation1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai 200031, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain
4.Aarhus Univ, Deparment Clin Med, Aarhus, Denmark
5.Tianjin Med Univ, Sch Basic Med Sci, Dept Pharmacol, Minist Educ, Tianjin 300070, Peoples R China
6.Tianjin Med Univ, Tianjin Key Lab Inflammatory Biol, Key Lab Immune Microenvironment & Dis, Minist Educ, Tianjin 300070, Peoples R China
7.Nanjing Med Univ, Key Lab Cardiovasc & Cerebrovasc Med, Nanjing 211100, Jiangsu, Peoples R China
8.Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Me, Nanjing 211100, Jiangsu, Peoples R China
9.Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China
10.Peking Union Med Coll, Beijing, Peoples R China
11.Jinan Univ, Minist Educ, Key Lab Regenerat Med, Guangzhou 510632, Guangdong, Peoples R China
12.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China
13.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Tang, Juan,Wang, Haixiao,Huang, Xiuzhen,et al. Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration[J]. CELL STEM CELL,2020,26(1):81-+.
APA Tang, Juan.,Wang, Haixiao.,Huang, Xiuzhen.,Li, Fei.,Zhu, Huan.,...&Zhou, Bin.(2020).Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration.CELL STEM CELL,26(1),81-+.
MLA Tang, Juan,et al."Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration".CELL STEM CELL 26.1(2020):81-+.
Files in This Item:
There are no files associated with this item.
Related Services
Usage statistics
Scholar Google
Similar articles in Scholar Google
[Tang, Juan]'s Articles
[Wang, Haixiao]'s Articles
[Huang, Xiuzhen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tang, Juan]'s Articles
[Wang, Haixiao]'s Articles
[Huang, Xiuzhen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tang, Juan]'s Articles
[Wang, Haixiao]'s Articles
[Huang, Xiuzhen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.