Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics
Jiang, Yihong1; Qi, Jia2,3; Xue, Xinli4; Huang, Rong1; Zheng, Jun1; Liu, Wei1; Yin, Huiyong4,5,6; Li, Shengxian1
2019-12-03
Source PublicationGYNECOLOGICAL ENDOCRINOLOGY
ISSN0951-3590
Status已发表
DOI10.1080/09513590.2019.1698026
AbstractThis study aimed to identify potential lipid biomarkers in women with polycystic ovary syndrome (PCOS) and determine their predictive value for PCOS. Eighteen women with PCOS and 17 healthy controls were enrolled. A multi-dimensional mass spectrometry-based shotgun lipidomics approach was employed to analyze serum lipid profiles. Shotgun lipidomics revealed that the concentrations of ceramide (Cer) and phosphatidylcholine (PC) were higher (PC: 831.6 +/- 217.4 vs. 605.2 +/- 164.2 mu mol/l; Cer: 3,387.6 +/- 829.9 vs. 2,552.2 +/- 679.4 nmol/l, respectively), whereas that of lysophosphatidylcholine was lower, in PCOS women than in healthy controls (82.02 +/- 39.49 vs. 133.62 +/- 65.36 mu mol/l, respectively). Receiver operating characteristic analysis showed that the combination of Cer (OH_N16:0/N18:0) and Cer (N22:0) had the greatest discriminatory power to differentiate between women with and without PCOS (area under the curve: 0.889, 95% confidence interval: 0.784-0.994). These results indicate that the combination of Cer (OH_N16:0/N18:0) and Cer (N22:0) may represent a novel lipid predictor of PCOS.
KeywordPolycystic ovary syndrome ceramide shotgun lipidomics insulin resistance
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2016YFD0400205]
WOS Research AreaEndocrinology & Metabolism ; Obstetrics & Gynecology
WOS SubjectEndocrinology & Metabolism ; Obstetrics & Gynecology
WOS IDWOS:000500143000001
PublisherTAYLOR & FRANCIS LTD
EISSN1473-0766
WOS KeywordINSULIN-RESISTANCE ; BIOLOGICAL SAMPLES ; SKELETAL-MUSCLE ; GLUCOSE ; PCOS
Original Document TypeArticle ; Early Access
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/104509
Collection生命科学与技术学院_特聘教授组_尹慧勇组
Corresponding AuthorYin, Huiyong; Li, Shengxian
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Endocrinol & Metab, Shanghai 200127, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Ctr Reprod Med, Shanghai, Peoples R China
3.Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai, Peoples R China
4.Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth, SIBS, Shanghai 200031, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
6.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Jiang, Yihong,Qi, Jia,Xue, Xinli,et al. Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics[J]. GYNECOLOGICAL ENDOCRINOLOGY,2019.
APA Jiang, Yihong.,Qi, Jia.,Xue, Xinli.,Huang, Rong.,Zheng, Jun.,...&Li, Shengxian.(2019).Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics.GYNECOLOGICAL ENDOCRINOLOGY.
MLA Jiang, Yihong,et al."Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics".GYNECOLOGICAL ENDOCRINOLOGY (2019).
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