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Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow | |
2019-10-22 | |
发表期刊 | CHEMISTRY-A EUROPEAN JOURNAL (IF:3.9[JCR-2023],4.1[5-Year]) |
ISSN | 0947-6539 |
EISSN | 1521-3765 |
卷号 | 25期号:64页码:14532-14535 |
发表状态 | 已发表 |
DOI | 10.1002/chem.201904480 |
摘要 | Transition-metal-catalyzed cross-coupling chemistry can be regarded as one of the most powerful protocols to construct carbon-carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop protocols that utilize cheaper and more sustainable metal sources. Herein, we report a selective, practical, and fast iron-based cross-coupling reaction that enables the formation of Csp-Csp(3) and Csp(2)-Csp(3) bonds. In a telescoped flow process, the reaction can be combined with the Grignard reagent synthesis. Moreover, flow allows the use of a supporting ligand to be avoided without eroding the reaction selectivity. |
关键词 | catalysis cross-coupling flow chemistry Grignard reagents iron |
URL | 查看原文 |
收录类别 | SCI ; SCIE ; EI ; IC ; CCR |
资助项目 | European Union[641861] |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Multidisciplinary |
WOS记录号 | WOS:000494090000001 |
出版者 | WILEY-V C H VERLAG GMBH |
EI入藏号 | 20194707712118 |
EI主题词 | Carbon ; Chemical bonds ; Chlorine compounds ; Iron |
EI分类号 | Iron:545.1 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Chemical Products Generally:804 |
WOS关键词 | TRANSITION-METALS |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102269 |
专题 | 物质科学与技术学院_特聘教授组_孙予罕组 物质科学与技术学院_博士生 |
共同第一作者 | Wei, Xiao-Jing |
通讯作者 | Noel, Timothy |
作者单位 | 1.Eindhoven Univ Technol, Micro Flow Chem & Synthet Methodol, Dept Chem Engn & Chem, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands 2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 3.Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China 4.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China |
第一作者单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Deng, Yuchao,Wei, Xiao-Jing,Wang, Xiao,et al. Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow[J]. CHEMISTRY-A EUROPEAN JOURNAL,2019,25(64):14532-14535. |
APA | Deng, Yuchao,Wei, Xiao-Jing,Wang, Xiao,Sun, Yuhan,&Noel, Timothy.(2019).Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow.CHEMISTRY-A EUROPEAN JOURNAL,25(64),14532-14535. |
MLA | Deng, Yuchao,et al."Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow".CHEMISTRY-A EUROPEAN JOURNAL 25.64(2019):14532-14535. |
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