Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow
2019-10-22
发表期刊CHEMISTRY-A EUROPEAN JOURNAL (IF:3.9[JCR-2023],4.1[5-Year])
ISSN0947-6539
EISSN1521-3765
卷号25期号:64页码:14532-14535
发表状态已发表
DOI10.1002/chem.201904480
摘要

Transition-metal-catalyzed cross-coupling chemistry can be regarded as one of the most powerful protocols to construct carbon-carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop protocols that utilize cheaper and more sustainable metal sources. Herein, we report a selective, practical, and fast iron-based cross-coupling reaction that enables the formation of Csp-Csp(3) and Csp(2)-Csp(3) bonds. In a telescoped flow process, the reaction can be combined with the Grignard reagent synthesis. Moreover, flow allows the use of a supporting ligand to be avoided without eroding the reaction selectivity.

关键词catalysis cross-coupling flow chemistry Grignard reagents iron
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收录类别SCI ; SCIE ; EI ; IC ; CCR
资助项目European Union[641861]
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000494090000001
出版者WILEY-V C H VERLAG GMBH
EI入藏号20194707712118
EI主题词Carbon ; Chemical bonds ; Chlorine compounds ; Iron
EI分类号Iron:545.1 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Chemical Products Generally:804
WOS关键词TRANSITION-METALS
原始文献类型Article
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102269
专题物质科学与技术学院_特聘教授组_孙予罕组
物质科学与技术学院_博士生
共同第一作者Wei, Xiao-Jing
通讯作者Noel, Timothy
作者单位
1.Eindhoven Univ Technol, Micro Flow Chem & Synthet Methodol, Dept Chem Engn & Chem, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands
2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
3.Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China
4.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
第一作者单位物质科学与技术学院
推荐引用方式
GB/T 7714
Deng, Yuchao,Wei, Xiao-Jing,Wang, Xiao,et al. Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow[J]. CHEMISTRY-A EUROPEAN JOURNAL,2019,25(64):14532-14535.
APA Deng, Yuchao,Wei, Xiao-Jing,Wang, Xiao,Sun, Yuhan,&Noel, Timothy.(2019).Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow.CHEMISTRY-A EUROPEAN JOURNAL,25(64),14532-14535.
MLA Deng, Yuchao,et al."Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow".CHEMISTRY-A EUROPEAN JOURNAL 25.64(2019):14532-14535.
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