Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants
Li, Yixuan1; Zhao, Sheng2; Li, Sirong2; Ge, Yuxiang1; Wang, Rongliang1; Zheng, Liming1; Xu, Jiankun3; Sun, Minghui4; Jiang, Qing1; Zhang, Yifeng1,5; Wei, Hui2,6,7
2019-11-22
Source PublicationSMALL
ISSN1613-6810
Status已发表
DOI10.1002/smll.201904486
AbstractMagnesium (Mg) alloys have been promised for biomedical implants in orthopedic field, however, the fast corrosion rate and mode challenge their clinical application. To push Mg alloys materials into practice, a composite coating with biodegradable and high compatible components to improve anticorrosion property of an Mg alloy (i.e., AZ31) is designed and fabricated. The inner layer is micro-nano structured Mg(OH)(2) through hydrothermal treatment. Then stearic acid (SA) is introduced to modify Mg(OH)(2) for better reducing the gap below a surface-degradation polymer layer of poly(1,3-trimethylene carbonate). Benefited by the SA modification effect, this sandwiched coating avoids corrosive medium penetration via enhancing the adhesion strength at the interface between outer and inner layers. Both in vitro and in vivo tests indicate that the composite coating modified AZ31 perform a better anticorrosion behavior and biocompatibility compared to bare AZ31. Strikingly, a 1.7-fold improvement in volume of newly formed bone is observed surrounding the composite coating modified implant after 12 week implantation. The sandwiched biocompatible coating strategy paves a hopeful way for future translational application of Mg alloys orthopedic materials in clinics.
Keywordbiodegradable implants bone generation composite coatings magnesium alloy
Indexed BySCI
Language英语
Funding ProjectScientific Research Foundation of Graduate School of Nanjing University[2016CL12]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000497884800001
PublisherWILEY-V C H VERLAG GMBH
EISSN1613-6829
WOS KeywordSTEARIC-ACID ; CORROSION-RESISTANCE ; TRIMETHYLENE CARBONATE ; DEGRADATION BEHAVIOR ; IN-VIVO ; CYTOCOMPATIBILITY ; ARTHROPLASTY ; CAPROLACTONE ; COMPOSITE ; MECHANISM
Original Document TypeArticle ; Early Access
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102253
Collection生命科学与技术学院_PI研究组_张翼锋组
Corresponding AuthorJiang, Qing; Zhang, Yifeng; Wei, Hui
Affiliation1.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Dept Sports Med & Adult Reconstruct Surg, Nanjing Drum Tower Hosp,Affiliated Hosp,Med Sch, Nanjing 210008, Jiangsu, Peoples R China
2.Nanjing Univ, Jiangsu Key Lab Artificial Funct Mat, Nanjing Natl Lab Microstruct, Coll Engn & Appl Sci, Nanjing 210093, Jiangsu, Peoples R China
3.Chinese Univ Hong Kong, Dept Orthoped & Traumatol, Musculoskeletal Res Lab, Hong Kong 999077, Peoples R China
4.Nanjing Univ, Affiliated Hosp, Nanjing Drum Tower Hosp, Dept Joint Surg,Med Sch, Nanjing 210008, Jiangsu, Peoples R China
5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
6.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China
7.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Li, Yixuan,Zhao, Sheng,Li, Sirong,et al. Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants[J]. SMALL,2019.
APA Li, Yixuan.,Zhao, Sheng.,Li, Sirong.,Ge, Yuxiang.,Wang, Rongliang.,...&Wei, Hui.(2019).Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants.SMALL.
MLA Li, Yixuan,et al."Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants".SMALL (2019).
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