Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants

doi:10.1002/smll.201904486

	Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants
	Li, Yixuan 1; Zhao, Sheng 2; Li, Sirong 2; Ge, Yuxiang 1; Wang, Rongliang 1; Zheng, Liming 1; Xu, Jiankun 3; Sun, Minghui 4; Jiang, Qing 1; Zhang, Yifeng1,5 ; Wei, Hui 2,6,7
	2019-11-22
发表期刊	SMALL
ISSN	1613-6810
EISSN	1613-6829
发表状态	已发表
DOI	10.1002/smll.201904486
摘要	Magnesium (Mg) alloys have been promised for biomedical implants in orthopedic field, however, the fast corrosion rate and mode challenge their clinical application. To push Mg alloys materials into practice, a composite coating with biodegradable and high compatible components to improve anticorrosion property of an Mg alloy (i.e., AZ31) is designed and fabricated. The inner layer is micro-nano structured Mg(OH)(2) through hydrothermal treatment. Then stearic acid (SA) is introduced to modify Mg(OH)(2) for better reducing the gap below a surface-degradation polymer layer of poly(1,3-trimethylene carbonate). Benefited by the SA modification effect, this sandwiched coating avoids corrosive medium penetration via enhancing the adhesion strength at the interface between outer and inner layers. Both in vitro and in vivo tests indicate that the composite coating modified AZ31 perform a better anticorrosion behavior and biocompatibility compared to bare AZ31. Strikingly, a 1.7-fold improvement in volume of newly formed bone is observed surrounding the composite coating modified implant after 12 week implantation. The sandwiched biocompatible coating strategy paves a hopeful way for future translational application of Mg alloys orthopedic materials in clinics.
关键词	biodegradable implants bone generation composite coatings magnesium alloy
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	Scientific Research Foundation of Graduate School of Nanjing University[2016CL12]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000497884800001
出版者	WILEY-V C H VERLAG GMBH
WOS关键词	STEARIC-ACID ; CORROSION-RESISTANCE ; TRIMETHYLENE CARBONATE ; DEGRADATION BEHAVIOR ; IN-VIVO ; CYTOCOMPATIBILITY ; ARTHROPLASTY ; CAPROLACTONE ; COMPOSITE ; MECHANISM
原始文献类型	Article ; Early Access
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102253
专题	生命科学与技术学院_PI研究组_张翼锋组
通讯作者	Jiang, Qing; Zhang, Yifeng; Wei, Hui
作者单位	1.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Dept Sports Med & Adult Reconstruct Surg, Nanjing Drum Tower Hosp,Affiliated Hosp,Med Sch, Nanjing 210008, Jiangsu, Peoples R China 2.Nanjing Univ, Jiangsu Key Lab Artificial Funct Mat, Nanjing Natl Lab Microstruct, Coll Engn & Appl Sci, Nanjing 210093, Jiangsu, Peoples R China 3.Chinese Univ Hong Kong, Dept Orthoped & Traumatol, Musculoskeletal Res Lab, Hong Kong 999077, Peoples R China 4.Nanjing Univ, Affiliated Hosp, Nanjing Drum Tower Hosp, Dept Joint Surg,Med Sch, Nanjing 210008, Jiangsu, Peoples R China 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China 7.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Yixuan,Zhao, Sheng,Li, Sirong,et al. Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants[J]. SMALL,2019.
APA	Li, Yixuan.,Zhao, Sheng.,Li, Sirong.,Ge, Yuxiang.,Wang, Rongliang.,...&Wei, Hui.(2019).Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants.SMALL.
MLA	Li, Yixuan,et al."Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants".SMALL (2019).