ShanghaiTech University Knowledge Management System
Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants | |
2019-11-22 | |
发表期刊 | SMALL |
ISSN | 1613-6810 |
EISSN | 1613-6829 |
发表状态 | 已发表 |
DOI | 10.1002/smll.201904486 |
摘要 | Magnesium (Mg) alloys have been promised for biomedical implants in orthopedic field, however, the fast corrosion rate and mode challenge their clinical application. To push Mg alloys materials into practice, a composite coating with biodegradable and high compatible components to improve anticorrosion property of an Mg alloy (i.e., AZ31) is designed and fabricated. The inner layer is micro-nano structured Mg(OH)(2) through hydrothermal treatment. Then stearic acid (SA) is introduced to modify Mg(OH)(2) for better reducing the gap below a surface-degradation polymer layer of poly(1,3-trimethylene carbonate). Benefited by the SA modification effect, this sandwiched coating avoids corrosive medium penetration via enhancing the adhesion strength at the interface between outer and inner layers. Both in vitro and in vivo tests indicate that the composite coating modified AZ31 perform a better anticorrosion behavior and biocompatibility compared to bare AZ31. Strikingly, a 1.7-fold improvement in volume of newly formed bone is observed surrounding the composite coating modified implant after 12 week implantation. The sandwiched biocompatible coating strategy paves a hopeful way for future translational application of Mg alloys orthopedic materials in clinics. |
关键词 | biodegradable implants bone generation composite coatings magnesium alloy |
收录类别 | SCI ; SCIE ; EI |
语种 | 英语 |
资助项目 | Scientific Research Foundation of Graduate School of Nanjing University[2016CL12] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
WOS记录号 | WOS:000497884800001 |
出版者 | WILEY-V C H VERLAG GMBH |
WOS关键词 | STEARIC-ACID ; CORROSION-RESISTANCE ; TRIMETHYLENE CARBONATE ; DEGRADATION BEHAVIOR ; IN-VIVO ; CYTOCOMPATIBILITY ; ARTHROPLASTY ; CAPROLACTONE ; COMPOSITE ; MECHANISM |
原始文献类型 | Article ; Early Access |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102253 |
专题 | 生命科学与技术学院_PI研究组_张翼锋组 |
通讯作者 | Jiang, Qing; Zhang, Yifeng; Wei, Hui |
作者单位 | 1.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Dept Sports Med & Adult Reconstruct Surg, Nanjing Drum Tower Hosp,Affiliated Hosp,Med Sch, Nanjing 210008, Jiangsu, Peoples R China 2.Nanjing Univ, Jiangsu Key Lab Artificial Funct Mat, Nanjing Natl Lab Microstruct, Coll Engn & Appl Sci, Nanjing 210093, Jiangsu, Peoples R China 3.Chinese Univ Hong Kong, Dept Orthoped & Traumatol, Musculoskeletal Res Lab, Hong Kong 999077, Peoples R China 4.Nanjing Univ, Affiliated Hosp, Nanjing Drum Tower Hosp, Dept Joint Surg,Med Sch, Nanjing 210008, Jiangsu, Peoples R China 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China 7.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Li, Yixuan,Zhao, Sheng,Li, Sirong,et al. Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants[J]. SMALL,2019. |
APA | Li, Yixuan.,Zhao, Sheng.,Li, Sirong.,Ge, Yuxiang.,Wang, Rongliang.,...&Wei, Hui.(2019).Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants.SMALL. |
MLA | Li, Yixuan,et al."Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants".SMALL (2019). |
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