Temperature-sensitive cytoophidium assembly in Schizosaccharomyces pombe
Zhang, Jing1; Liu, Ji-Long1,2
2019-09-20
发表期刊JOURNAL OF GENETICS AND GENOMICS
ISSN1673-8527
EISSN1873-5533
卷号46期号:9页码:423-432
发表状态已发表
DOI10.1016/j.jgg.2019.09.002
摘要

The metabolic enzyme CTP synthase (CTPS) is able to compartmentalize into filaments, termed cytoophidia, in a variety of organisms including bacteria, budding yeast, fission yeast, fruit flies and mammals. A previous study in budding yeast shows that the filament-forming process of CTPS is not sensitive to temperature shift. Here we study CTPS filamentation in the fission yeast Schizosaccharomyces pombe. To our surprise, we find that both the length and the occurrence of cytoophidia in S. pombe decrease upon cold shock or heat shock. The temperature-dependent changes of cytoophidia are fast and reversible. Taking advantage of yeast genetics, we demonstrate that heat-shock proteins are required for cytoophidium assembly in S. pombe. Temperature sensitivity of cytoophidia makes S. pombe an attractive model system for future investigations of this novel membraneless organelle. Copyright (C) 2019, The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press.

关键词CTP synthase Cytoophidium Schizosaccharomyces pombe Heat-shock protein Nucleoside/nucleotide metabolism Cell biology Yeast genetics Cell compartmentalization
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收录类别SCI ; SCIE ; CSCD
资助项目UK Medical Research Council[MC_UU_12021/3] ; UK Medical Research Council[MC_U137788471]
WOS研究方向Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号WOS:000498167900002
CSCD记录号CSCD:6614099
出版者SCIENCE PRESS
WOS关键词CTP SYNTHASE ; METABOLIC ENZYMES ; COMPARTMENTATION ; FILAMENTATION
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102224
专题生命科学与技术学院_PI研究组_刘冀珑组
通讯作者Liu, Ji-Long
作者单位1.Univ Oxford, Dept Physiol Anat & Genet, MRC, Funct Genom Unit, Oxford OX1 3PT, England
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位生命科学与技术学院
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Zhang, Jing,Liu, Ji-Long. Temperature-sensitive cytoophidium assembly in Schizosaccharomyces pombe[J]. JOURNAL OF GENETICS AND GENOMICS,2019,46(9):423-432.
APA Zhang, Jing,&Liu, Ji-Long.(2019).Temperature-sensitive cytoophidium assembly in Schizosaccharomyces pombe.JOURNAL OF GENETICS AND GENOMICS,46(9),423-432.
MLA Zhang, Jing,et al."Temperature-sensitive cytoophidium assembly in Schizosaccharomyces pombe".JOURNAL OF GENETICS AND GENOMICS 46.9(2019):423-432.
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