Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded

doi:10.1038/celldisc.2015.47

	Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded
	Hu, Lianxin 1; Xu, Jiajun 1; Yin, Meng-Xin 1; Zhang, Liguo 2; Lu, Yi 1; Wu, Wenqing 1; Xue, Zhaoyu 3; Ho, Margaret S.4; Gao, Guanjun 3; Zhao, Yun1,5 ; Zhang, Lei1,5
	2016-02-23
发表期刊	CELL DISCOVERY
ISSN	2056-5968
卷号	2
发表状态	已发表
DOI	10.1038/celldisc.2015.47
摘要	Non-receptor tyrosine kinase activated cdc42 kinase was reported to participate in several types of cancers in mammals. It is also believed to have an anti-apoptotic function in Drosophila. Here, we report the identification of Drosophila activated cdc42 kinase as a growth promoter and a novel Hippo signaling pathway regulator. We find that activated cdc42 kinase promotes tissue growth through modulating Yorkie activity. Furthermore, we demonstrate that activated cdc42 kinase interacts with Expanded and induces tyrosine phosphorylation of Expanded on multiple sites. We propose a model that activated cdc42 kinase negatively regulates Expanded by changing its phosphorylation status to promote tissue growth. Moreover, we show that ack genetically interacts with merlin and expanded. Thus, we identify Drosophila activated cdc42 kinase as a Hippo pathway regulator.
关键词	Hippo pathway activated cdc43 kinase Yorkie expanded
收录类别	SCI
语种	英语
资助项目	State Key Program of National Natural Science of China[31530043]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000414789000001
出版者	NATURE PUBLISHING GROUP
WOS关键词	ORGAN SIZE CONTROL ; CELL-CYCLE EXIT ; TYROSINE KINASE ACK1 ; TUMOR-SUPPRESSOR ; SIGNALING PATHWAY ; PROLIFERATION ARREST ; PROSTATE-CANCER ; BANTAM MICRORNA ; MOSAIC ANALYSIS ; DORSAL CLOSURE
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/10038
专题	生命科学与技术学院_特聘教授组_赵允组生命科学与技术学院_特聘教授组_张雷组
通讯作者	Zhang, Lei
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network,State Key Lab, Shanghai, Peoples R China 2.Univ Illinois, Dept Cell & Dev Biol, Urbana, IL USA 3.Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China 4.Tongji Univ, Sch Med, Dept Anat & Neurobiol, Shanghai, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Hu, Lianxin,Xu, Jiajun,Yin, Meng-Xin,et al. Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded[J]. CELL DISCOVERY,2016,2.
APA	Hu, Lianxin.,Xu, Jiajun.,Yin, Meng-Xin.,Zhang, Liguo.,Lu, Yi.,...&Zhang, Lei.(2016).Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.CELL DISCOVERY,2.
MLA	Hu, Lianxin,et al."Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded".CELL DISCOVERY 2(2016).