ShanghaiTech University Knowledge Management System
Increased complexity of circRNA expression during species evolution | |
Dong, Rui1,3; Ma, Xu-Kai1,3; Chen, Ling-Ling2,3,4; Yang, Li1,3,4 | |
2017 | |
发表期刊 | RNA BIOLOGY |
ISSN | 1547-6286 |
卷号 | 14期号:8页码:1064-1074 |
发表状态 | 已发表 |
DOI | 10.1080/15476286.2016.1269999 |
摘要 | Circular RNAs (circRNAs) are broadly identified from precursor mRNA (pre-mRNA) back-splicing across various species. Recent studies have suggested a cell-/tissue- specific manner of circRNA expression. However, the distinct expression pattern of circRNAs among species and its underlying mechanism still remain to be explored. Here, we systematically compared circRNA expression from human and mouse, and found that only a small portion of human circRNAs could be determined in parallel mouse samples. The conserved circRNA expression between human and mouse is correlated with the existence of orientation-opposite complementary sequences in introns that flank back-spliced exons in both species, but not the circRNA sequences themselves. Quantification of RNA pairing capacity of orientation-opposite complementary sequences across circRNA-flanking introns by Complementary Sequence Index (CSI) identifies that among all types of complementary sequences, SINEs, especially Alu elements in human, contribute the most for circRNA formation and that their diverse distribution across species leads to the increased complexity of circRNA expression during species evolution. Together, our integrated and comparative reference catalog of circRNAs in different species reveals a species-specific pattern of circRNA expression and suggests a previously under-appreciated impact of fast-evolved SINEs on the regulation of (circRNA) gene expression. |
关键词 | Alu back-splicing circRNA complementary sequence evolution SINE species-specific |
收录类别 | SCI |
语种 | 英语 |
资助项目 | NSFC[91540115] ; NSFC[91440202] ; NSFC[31271390] ; NSFC[31471241] |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:000415997500013 |
出版者 | TAYLOR & FRANCIS INC |
WOS关键词 | CIRCULAR RNAS ; BIOGENESIS ; LANDSCAPE ; ABUNDANT ; REVEALS ; GENE |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/10023 |
专题 | 生命科学与技术学院 生命科学与技术学院_特聘教授组_杨力组 生命科学与技术学院_特聘教授组_陈玲玲组 |
通讯作者 | Chen, Ling-Ling; Yang, Li |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,CAS Ctr Excellence Brain Sc, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Dong, Rui,Ma, Xu-Kai,Chen, Ling-Ling,et al. Increased complexity of circRNA expression during species evolution[J]. RNA BIOLOGY,2017,14(8):1064-1074. |
APA | Dong, Rui,Ma, Xu-Kai,Chen, Ling-Ling,&Yang, Li.(2017).Increased complexity of circRNA expression during species evolution.RNA BIOLOGY,14(8),1064-1074. |
MLA | Dong, Rui,et al."Increased complexity of circRNA expression during species evolution".RNA BIOLOGY 14.8(2017):1064-1074. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。