Increased complexity of circRNA expression during species evolution
Dong, Rui1,3; Ma, Xu-Kai1,3; Chen, Ling-Ling2,3,4; Yang, Li1,3,4
2017
发表期刊RNA BIOLOGY
ISSN1547-6286
卷号14期号:8页码:1064-1074
发表状态已发表
DOI10.1080/15476286.2016.1269999
摘要

Circular RNAs (circRNAs) are broadly identified from precursor mRNA (pre-mRNA) back-splicing across various species. Recent studies have suggested a cell-/tissue- specific manner of circRNA expression. However, the distinct expression pattern of circRNAs among species and its underlying mechanism still remain to be explored. Here, we systematically compared circRNA expression from human and mouse, and found that only a small portion of human circRNAs could be determined in parallel mouse samples. The conserved circRNA expression between human and mouse is correlated with the existence of orientation-opposite complementary sequences in introns that flank back-spliced exons in both species, but not the circRNA sequences themselves. Quantification of RNA pairing capacity of orientation-opposite complementary sequences across circRNA-flanking introns by Complementary Sequence Index (CSI) identifies that among all types of complementary sequences, SINEs, especially Alu elements in human, contribute the most for circRNA formation and that their diverse distribution across species leads to the increased complexity of circRNA expression during species evolution. Together, our integrated and comparative reference catalog of circRNAs in different species reveals a species-specific pattern of circRNA expression and suggests a previously under-appreciated impact of fast-evolved SINEs on the regulation of (circRNA) gene expression.

关键词Alu back-splicing circRNA complementary sequence evolution SINE species-specific
收录类别SCI
语种英语
资助项目NSFC[91540115] ; NSFC[91440202] ; NSFC[31271390] ; NSFC[31471241]
WOS研究方向Biochemistry & Molecular Biology
WOS类目Biochemistry & Molecular Biology
WOS记录号WOS:000415997500013
出版者TAYLOR & FRANCIS INC
WOS关键词CIRCULAR RNAS ; BIOGENESIS ; LANDSCAPE ; ABUNDANT ; REVEALS ; GENE
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/10023
专题生命科学与技术学院
生命科学与技术学院_特聘教授组_杨力组
生命科学与技术学院_特聘教授组_陈玲玲组
通讯作者Chen, Ling-Ling; Yang, Li
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,CAS Ctr Excellence Brain Sc, Shanghai, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Shanghai, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位生命科学与技术学院
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GB/T 7714
Dong, Rui,Ma, Xu-Kai,Chen, Ling-Ling,et al. Increased complexity of circRNA expression during species evolution[J]. RNA BIOLOGY,2017,14(8):1064-1074.
APA Dong, Rui,Ma, Xu-Kai,Chen, Ling-Ling,&Yang, Li.(2017).Increased complexity of circRNA expression during species evolution.RNA BIOLOGY,14(8),1064-1074.
MLA Dong, Rui,et al."Increased complexity of circRNA expression during species evolution".RNA BIOLOGY 14.8(2017):1064-1074.
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