Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila

doi:10.1038/celldisc.2015.6

	Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila
	Han, Hui 1; Pan, Chenyu 1; Liu, Chunying 1; Lv, Xiangdong 1; Yang, Xiaofeng 1; Xiong, Yue 1; Lu, Yi 1; Wu, Wenqing 1; Han, Junhai 2; Zhou, Zhaocai 1; Jiang, Hai 1; Zhang, Lei 1; Zhao, Yun1,3
	2015
发表期刊	CELL DISCOVERY
ISSN	2056-5968
卷号	1
发表状态	已发表
DOI	10.1038/celldisc.2015.6
摘要	Intestinal homeostasis is maintained by intestinal stem cells (ISCs) and their progenies. A complex autonomic nervous system spreads over posterior intestine. However, whether and how neurons regulate posterior intestinal homeostasis is largely unknown. Here we report that neurons regulate Drosophila posterior intestinal homeostasis. Specifically, down-regulation of neuronal Hedgehog (Hh) signaling inhibits the differentiation of ISCs toward enterocytes (ECs), whereas upregulated neuronal Hh signaling promotes such process. We demonstrate that, among multiple sources of Hh ligand, those secreted by ECs induces similar phenotypes as does neuronal Hh. In addition, intestinal JAK/STAT signaling responds to activated neuronal Hh signaling, suggesting that JAK/STAT signaling acts downstream of neuronal Hh signaling in intestine. Collectively, our results indicate that neuronal Hh signaling is essential for the determination of ISC fate.
关键词	Hh signaling intestinal stem cell neuron Drosophila
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31171414] ; National Natural Science Foundation of China[31371492] ; National Natural Science Foundation of China[31301187]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000414776800006
出版者	NATURE PUBLISHING GROUP
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/10019
专题	生命科学与技术学院_特聘教授组_赵允组
通讯作者	Zhao, Yun
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai, Peoples R China 2.Southeast Univ, Inst Life Sci, Key Lab Dev Genes & Human Dis, Nanjing, Jiangsu, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanhghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Han, Hui,Pan, Chenyu,Liu, Chunying,et al. Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila[J]. CELL DISCOVERY,2015,1.
APA	Han, Hui.,Pan, Chenyu.,Liu, Chunying.,Lv, Xiangdong.,Yang, Xiaofeng.,...&Zhao, Yun.(2015).Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila.CELL DISCOVERY,1.
MLA	Han, Hui,et al."Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila".CELL DISCOVERY 1(2015).