Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium

doi:10.1055/s-0043-110227

	Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium
	Du, Qizhen 1,2; Zhao, Yongchun 2,3,4; Liu, Hongchun 5; Tang, Chunping 3,4; Zhang, Minmin 5; Ke, Changqiang 3,4; Ye, Yang3,4,6
	2017-11
发表期刊	PLANTA MEDICA (IF:2.1[JCR-2023],2.8[5-Year])
ISSN	0032-0943
卷号	83 期号:17 页码:1361-1367
发表状态	已发表
DOI	10.1055/s-0043-110227
摘要	Nine new and eleven known phorbol esters were isolated from an acetone extract of the seeds of Croton tiglium. Their structures were determined by extensive analysis of spectroscopic data. Eleven of these compounds were evaluated for their inhibition activity on human tumor cell lines HL-60 and lung carcinoma A549. 12-O-Tiglylphorbol-13-acetate (11), 12-O-(2-methyl)-butyrylphorbol-13-aetate (12), and 12-O-tiglylphorbol-13-isobutyrate (13) exhibited strong inhibition activity against both HL-60 and A549 cell lines with IC50 values <= 0.02 and <= 0.1 mu g/mL, respectively. Compound 18 showed strong inhibition activity against the HL-60 cell line with an IC50 value of 0.02 mu g/mL.
关键词	Croton tiglium Euphorbiaceae phorbol esters isolation structure elucidation cytotoxicity
收录类别	SCI
语种	英语
资助项目	Bureau of Science & Technology for Development, Chinese Academy of Sciences[ZSTH-009] ; Bureau of Science & Technology for Development, Chinese Academy of Sciences[ZSTH-014]
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000415715200007
出版者	GEORG THIEME VERLAG KG
WOS关键词	DITERPENOIDS ; EXTRACTS ; L.
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/10014
专题	生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Ye, Yang
作者单位	1.Zhejiang A&F Univ, Key Lab Qual Improvement Agr Prod Zhejiang Prov, Coll Agr & Food Sci, Linan, Peoples R China 2.Zhejiang Gongshang Univ, Inst Food Chem, Hangzhou, Zhejiang, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Du, Qizhen,Zhao, Yongchun,Liu, Hongchun,et al. Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium[J]. PLANTA MEDICA,2017,83(17):1361-1367.
APA	Du, Qizhen.,Zhao, Yongchun.,Liu, Hongchun.,Tang, Chunping.,Zhang, Minmin.,...&Ye, Yang.(2017).Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium.PLANTA MEDICA,83(17),1361-1367.
MLA	Du, Qizhen,et al."Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium".PLANTA MEDICA 83.17(2017):1361-1367.